Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC045
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-02 10:52
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/4 caps Madopar a 125mg 1 uvece Old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 31, 'TN': 26, 'TP': 11, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 24, 'TN': 19, 'TP': 18, 'FP': 11}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 15, 'TN': 9, 'TP': 27, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 11.548
timePerCircleCoV 0.153541
timePerCircleSlope -0.046331
meanError 1.24465
tremorFreq 6.83594
tremorRelPower 29.8334
tremorGyroAmpMean 0.0164947
tremorGyroAmpSlope 0.00222439
tremorGyroAmpCoV 0.631476
tremorCoordAmpMean 0.0309812
tremorCoordAmpSlope 0.00219763
tremorCoordAmpCoV 0.442603
tremorAccAmpMean 0.0226334
tremorAccAmpSlope 0.000410772
tremorAccAmpCoV 0.564339
tremorPcRelVar 0.652904
tremorPcX 0.966026
tremorPcY -0.258444

Circle Segment 1

Duration 14.68 s, Accuracy Estimate 1.184 (lower is better)

Circle Segment 2

Duration 13.92 s, Accuracy Estimate 1.168 (lower is better)

Circle Segment 3

Duration 11.92 s, Accuracy Estimate 1.169 (lower is better)

Circle Segment 4

Duration 11.12 s, Accuracy Estimate 1.049 (lower is better)

Circle Segment 5

Duration 11.8 s, Accuracy Estimate 1.155 (lower is better)

Circle Segment 6

Duration 11.84 s, Accuracy Estimate 0.904 (lower is better)

Circle Segment 7

Duration 10.6 s, Accuracy Estimate 0.949 (lower is better)

Circle Segment 8

Duration 10.92 s, Accuracy Estimate 0.837 (lower is better)

Circle Segment 9

Duration 10.16 s, Accuracy Estimate 1.236 (lower is better)

Circle Segment 10

Duration 8.52 s, Accuracy Estimate 2.794 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 35.785
timePerSpiralCoV 0.170309
timePerSpiralSlope -0.0648716
meanError 1.66649
tremorFreq 5.76172
tremorRelPower 25.4213
tremorGyroAmpMean 0.0236562
tremorGyroAmpSlope -0.00126052
tremorGyroAmpCoV 0.358571
tremorCoordAmpMean 0.0369409
tremorCoordAmpSlope -0.000429689
tremorCoordAmpCoV 0.341285
tremorAccAmpMean 0.0897003
tremorAccAmpSlope -0.000140529
tremorAccAmpCoV 0.0742604
tremorPcRelVar 0.580713
tremorPcX -0.957863
tremorPcY -0.287227

Spiral Segment 1

Duration 42.08 s, Accuracy Estimate 1.668 (lower is better)

Spiral Segment 2

Duration 42.6 s, Accuracy Estimate 1.79 (lower is better)

Spiral Segment 3

Duration 37.52 s, Accuracy Estimate 1.492 (lower is better)

Spiral Segment 4

Duration 37.68 s, Accuracy Estimate 1.583 (lower is better)

Spiral Segment 5

Duration 38.8 s, Accuracy Estimate 1.528 (lower is better)

Spiral Segment 6

Duration 33.48 s, Accuracy Estimate 1.761 (lower is better)

Spiral Segment 7

Duration 27.64 s, Accuracy Estimate 1.625 (lower is better)

Spiral Segment 8

Duration 26.48 s, Accuracy Estimate 1.886 (lower is better)

Elel

eDurationMean 0.812237
eDurationStd 0.13646
eDurationStdnorm 0.168005
eDurationMedian 0.7975
eDurationQuartdelta 0.155
eDurationQuartdeltanorm 0.194357
eDurationKurt 6.99337
eDurationTrenddiff -0.065
eDurationTrendratio 0.921212
eWidthMean 6.89684
eWidthStd 1.33593
eWidthStdnorm 0.193702
eWidthMedian 7.0785
eWidthQuartdelta 1.638
eWidthQuartdeltanorm 0.231405
eWidthKurt 3.48923
eWidthTrenddiff 0.819
eWidthTrendratio 1.125
eHeightMean 15.6934
eHeightStd 1.96291
eHeightStdnorm 0.125079
eHeightMedian 15.795
eHeightQuartdelta 2.808
eHeightQuartdeltanorm 0.177778
eHeightKurt 2.65856
eHeightTrenddiff 2.457
eHeightTrendratio 1.175
eAspectMean 0.439844
eAspectStd 0.068924
eAspectStdnorm 0.156701
eAspectMedian 0.445523
eAspectQuartdelta 0.0753832
eAspectQuartdeltanorm 0.169201
eAspectKurt 3.22858
eAspectTrenddiff -0.0021575
eAspectTrendratio 0.995169
eSlantMean 0.147941
eSlantStd 0.0814221
eSlantStdnorm 0.550368
eSlantMedian 0.146281
eSlantQuartdelta 0.1
eSlantQuartdeltanorm 0.683614
eSlantKurt 2.74718
eSlantTrenddiff -0.0173611
eRtopMean 0.829987
eRtopStd 0.0750876
eRtopStdnorm 0.0904684
eRtopMedian 0.839497
eRtopQuartdelta 0.0810047
eRtopQuartdeltanorm 0.0964919
eRtopKurt 3.99403
eRtopTrenddiff -0.0173176
eRbotMean 0.500014
eRbotStd 0.138287
eRbotStdnorm 0.276567
eRbotMedian 0.484127
eRbotQuartdelta 0.158073
eRbotQuartdeltanorm 0.326512
eRbotKurt 3.71291
eRbotTrenddiff 0.0320062
eRrightMean 0.911764
eRrightStd 0.0449845
eRrightStdnorm 0.0493379
eRrightMedian 0.913779
eRrightQuartdelta 0.062905
eRrightQuartdeltanorm 0.0688405
eRrightKurt 2.37328
eRrightTrenddiff -0.0118414
eRleftMean 0.282636
eRleftStd 0.1024
eRleftStdnorm 0.362305
eRleftMedian 0.266146
eRleftQuartdelta 0.131874
eRleftQuartdeltanorm 0.495493
eRleftKurt 5.3762
eRleftTrenddiff 0.0416667
lDurationMean 1.27625
lDurationStd 0.218077
lDurationStdnorm 0.170873
lDurationMedian 1.2475
lDurationQuartdelta 0.3
lDurationQuartdeltanorm 0.240481
lDurationKurt 2.51065
lDurationTrenddiff -0.2475
lDurationTrendratio 0.824779
lWidthMean 14.8883
lWidthStd 1.70102
lWidthStdnorm 0.114253
lWidthMedian 14.625
lWidthQuartdelta 1.872
lWidthQuartdeltanorm 0.128
lWidthKurt 3.50593
lWidthTrenddiff -0.117
lWidthTrendratio 0.992032
lHeightMean 37.8934
lHeightStd 3.52827
lHeightStdnorm 0.0931105
lHeightMedian 37.4985
lHeightQuartdelta 4.797
lHeightQuartdeltanorm 0.127925
lHeightKurt 2.44644
lHeightTrenddiff 1.755
lHeightTrendratio 1.04724
lAspectMean 0.394702
lAspectStd 0.0447962
lAspectStdnorm 0.113494
lAspectMedian 0.39686
lAspectQuartdelta 0.0580754
lAspectQuartdeltanorm 0.146337
lAspectKurt 3.20729
lAspectTrenddiff -0.0102995
lAspectTrendratio 0.974255
lSlantMean 0.270281
lSlantStd 0.0584355
lSlantStdnorm 0.216203
lSlantMedian 0.273653
lSlantQuartdelta 0.069346
lSlantQuartdeltanorm 0.253409
lSlantKurt 3.50393
lSlantTrenddiff -0.0199388
lRtopMean 0.903057
lRtopStd 0.060054
lRtopStdnorm 0.0665008
lRtopMedian 0.916689
lRtopQuartdelta 0.0833169
lRtopQuartdeltanorm 0.090889
lRtopKurt 3.72011
lRtopTrenddiff -0.0159908
lRbotMean 0.22105
lRbotStd 0.091553
lRbotStdnorm 0.414173
lRbotMedian 0.217759
lRbotQuartdelta 0.122997
lRbotQuartdeltanorm 0.564829
lRbotKurt 2.75291
lRbotTrenddiff 0.0571731
lRrightMean 0.94995
lRrightStd 0.0314583
lRrightStdnorm 0.0331157
lRrightMedian 0.952289
lRrightQuartdelta 0.0370301
lRrightQuartdeltanorm 0.0388854
lRrightKurt 2.73389
lRrightTrenddiff -0.0165861
lRleftMean 0.109583
lRleftStd 0.0402304
lRleftStdnorm 0.367123
lRleftMedian 0.104037
lRleftQuartdelta 0.0417708
lRleftQuartdeltanorm 0.401502
lRleftKurt 4.18347
lRleftTrenddiff 0.000402503

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.832088
sumTouchScores 14.9776
meanMovementTime 0.980882
numTouches 18
undershootPercentage 0
overshootPercentage 22.2222

FITTS Long Modified

meanTouchScore 0.850996
sumTouchScores 12.7649
meanMovementTime 1.32
numTouches 15
undershootPercentage 6.66667
overshootPercentage 6.66667

ZigZag

numZigzags 5
timePerZigzagMean 32.08
timePerZigzagCoV 0.0782015
timePerZigzagSlope 0.0306733
meanError 2.19253
tremorFreq 5.95703
tremorRelPower 28.1044
tremorGyroAmpMean 0.0405437
tremorGyroAmpSlope 0.0024032
tremorGyroAmpCoV 0.399482
tremorCoordAmpMean 0.0642545
tremorCoordAmpSlope 0.000123285
tremorCoordAmpCoV 0.296444
tremorAccAmpMean 0.0518964
tremorAccAmpSlope -0.000761234
tremorAccAmpCoV 0.363029
tremorPcRelVar 0.572944
tremorPcX -0.722582
tremorPcY -0.691285

ZigZag Segment 1

Duration 28.6 s, Accuracy Estimate 2.416 (lower is better)

ZigZag Segment 2

Duration 32.0 s, Accuracy Estimate 2.29 (lower is better)

ZigZag Segment 3

Duration 34.84 s, Accuracy Estimate 1.99 (lower is better)

ZigZag Segment 4

Duration 30.88 s, Accuracy Estimate 2.034 (lower is better)

ZigZag Segment 5

Duration 34.08 s, Accuracy Estimate 2.232 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 23.008
timePerZigzagCoV 0.177267
timePerZigzagSlope -0.0851878
zigzagHeightMean 50.8366
zigzagHeightCoV 0.103152
zigzagHeightSlope -0.0613314
meanError 0.0362921
tremorFreq 7.12891
tremorRelPower 25.2579
tremorGyroAmpMean 0.0285777
tremorGyroAmpSlope 0.00294305
tremorGyroAmpCoV 0.384529
tremorCoordAmpMean 0.0615106
tremorCoordAmpSlope 0.00221052
tremorCoordAmpCoV 0.364331
tremorAccAmpMean 0.0507118
tremorAccAmpSlope 0.00230438
tremorAccAmpCoV 0.356456
tremorPcRelVar 0.8061
tremorPcX -0.0105152
tremorPcY -0.999945

ZigZag Offset Segment 1

Duration 24.52 s, Accuracy Estimate 0.022 (lower is better)

ZigZag Offset Segment 2

Duration 25.84 s, Accuracy Estimate 0.038 (lower is better)

ZigZag Offset Segment 3

Duration 27.24 s, Accuracy Estimate 0.062 (lower is better)

ZigZag Offset Segment 4

Duration 19.6 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 5

Duration 17.84 s, Accuracy Estimate 0.026 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.66}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.1336341101764713}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.4663592601135853}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.3446445594469443}